1.      Lu S., Huang H., Wang Y., Strongin AY., Wang Y. (2013) Highly Sensitive FRET Biosensors for Detecting MMP Activity in Live Breast Cancer Cells, PLoS ONE, Accepted

2.      Seong J., Wang N., Wang Y. (2013) Mechanotransduction at Focal Adhesions: from Physiology to Cancer Development, Journal of Cellular and Molecular Medicine, Accepted

3.      Ouyang M., Lu S., Chen CN., Kim T., Seong J., Leckband DE., Wang F., Reynolds AB., Schwartz MA., Wang Y. (2013) N-cadherin Differentially Couples with p120ctn and b-catenin to Regulate the Polarity of Distinct Molecular Activities, Nature Communications, Accepted

4.      Lin L.-J., Grimme J.M., Sun J., Lu S., Gai L., Cropek D.M., Wang Y. (2013) The antagonistic roles of PDGF and integrin αvβ3 in regulating ROS production at focal adhesions, Biomaterials, Accepted


5.      Qian T., Lu S., Ma H., Fang J., Zhong W., Wang Y. (2012) FRET Imaging of Microenvironment Effects on Calcium Signaling in Live Cells, Integrative Biology, Accepted

6.      Wang R., Lei L., Wang Y., Levine A.J., and Popescu G. (2012) Dispersion-relation fluorescence spectroscopy, Physics Review Letter, Accepted

7.      *Liao X., *Lu S., Zhuo Y., Wang Y. (2012) Visualization of Src and FAK activity during the differentiation process from HMSCs to osteoblast by FRET biosensor, PLoS ONE, Accepted

8.      Eichorst JP., Clegg RM., Wang Y. (2012), Red-Shifted Fluorescent Proteins Monitor Enzymatic Activity in Live HT-1080 Cells with Fluorescence Lifetime Imaging Microscopy (FLIM), Journal of Microscopy, Accepted

9.      Birukova A.A., Tian Y., Dubrovskyi O., Zebda N., Sarich N., Tian X., Wang Y., Birukov K.G. (2012) VE-cadherin Trans-interactions Modulate Rac Activation and Enhancement of Lung Endothelial Barrier by Iloprost, Journal of Cellular Physiology, Accepted

10.  Ouyang M., Lu S., Wang Y. (2012) Genetically Encoded Fluorescent Biosensors for Live-cell Imaging of MT1-MMP Protease Activity, Methods in Molecular Biology, In Press


11.  *Xiang X., *Sun J., Wu J., He H.T., Wang Y., Zhu C. (2011) A FRET-based biosensor for imaging SYK activities in living cells, Cellular and Molecular Bioengineering, Accepted

12.  Nishitani WS., Saif TA, Wang Y. (2011) Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels, PLoS ONE, Accepted

13.  *Liao X., *Lu S., Zhuo Y., Winter C., Xu W., Li B., Wang Y. (2011) Bone physiology, biomaterial and the Effect of mechanical/physical microenvironment on mesenchymal stem cell osteogenesis, Cellular and Molecular Bioengineering, Accepted

14.  Seong J., Ouyang M., Kim T., Sun J., Wen P.-C., Lu S., Zhuo Y., Llewellyn N.M., Schlaepfer D.D., Guan J.L., Chien S., Wang Y. (2011) Detection of focal adhesion kinase activation at Membrane Microdomains by fluorescence resonance energy transfer, Nature Communications, Accepted

15.  Lu S., Kim T., Chen CN., Ouyang M., Seong J., Wang Y. (2011) Computational Analysis of the Spatiotemporal Coordination of Molecular Activities in Live Cells, PLoS ONE, 6(6):e21293

16.  Eichorst JP., Huang H., Clegg RM., Wang Y. (2011) Phase differential enhancement to distinguish fluorescence components when monitoring molecular activity in live cells by FLIM, Journal of Fluorescence, 21(4):1763-77

17.  Liu B., Lu S., Zheng S., Jiang Z.-L., Wang Y. (2011) Two Distinct Phases of Calcium Signaling under Flow, Cardiovascular Research, 91(1):124-33

18.  Seong J., Lu S., Wang, Y. (2011) Live Cell Imaging of Molecular Signaling by FRET, Cellular and Molecular Bioengineering, 4(2):138-147

19.  Butler P.J., Wang, Y. (2011) Editorial Note: Molecular Imaging and Mechanobiology, Cellular and Molecular Bioengineering, 4(2):123-124

20.  Asada HH., Wang Y., Mayalu MN. (2011) Molecular Signaling Observer and Predictor: A Framework for Closed-Loop Control of Cell Behaviors Having Long Time Delay, American Control Conference. 1240:2314-2319


21.  Lu, S., Wang, Y. (2010) FRET Biosensors for Cancer Detection and Evaluation of Drug Efficacy, Clinical Cancer Research, 16(15):3822-4

22.  Gawlik K., Remacle AG., Shiryaev SA., Golubkov VS., Ouyang M., Wang Y., and Strongin AY. (2010) A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen, PLoS ONE, 5(6):e11305

23.  Qian T., Wang Y. (2010) Micro/nano-fabrication Technologies for Cell Biology. Medical & Biological Engineering & Computing, 48(10):1023-32

24.  Liu B., Kim T., Wang Y. (2010) Live Cell Imaging of Mechanotransduction. Journal of the Royal Society Interface, 7 Suppl 3:S365-75

25.  Ouyang M.*, Huang H.*, Shaner N., Remacle AG., Shiryaev SA., Strongin AY., Tsien RY., Wang Y. (2010) Simultaneous Visualization of Pro-tumorigenic Src and MT1-MMP Activities with Fluorescence Resonance Energy Transfer. Cancer Research, 70(6):2204-12


26.  Poh Y.C., Na S., Chowdhury F., Ouyang M., Wang Y., Wang N. (2009) Rapid Activation of Rac GTPase in Living Cells by Force Is Independent of Src. PLoS ONE, 4(11):e7886

27.  Wang Y., Wang N. (2009) FRET and Mechanobiology. Integrative Biology, 1(10):565-73 (Top Ten Article)

28.  Wang Y.*, Flores L.*, Lu S., Miao H., Li Y.-S., Chien S. (2009) Shear Stress Regulates the Flk-1/Cbl/PI3K/NF-kB Pathway via Actin and Tyrosine Kinases. Cellular and Molecular Bioengineering, 2(3):341-350

29.  Kim T., Wang Y. (2009) Single cell imaging of calcium dynamics in response to mechanical stimulation. Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling, 10:265-279

30.  Lu S., Wang Y. (2009) Application of FRET Biosensors and Computational Analysis for Live Cell Imaging. Proc. of SPIE. 7191 (719108):1-12

31.  Kim T., Xu J., Dong R., Lu S., Nuzzo R., Wang Y. (2009) Visualizing the Effect of Microenvironment on the Spatiotemporal RhoA and Src Activities in Live Cells by FRET. Small, 5(12):1453-9.

32.  Na S., Chowdhury F., Tay B., Ouyang M., Gregor M., Wang Y., Wiche G., Wang N. (2009) Plectin contributes to mechanical properties of living cells. Am J Physiol Cell Physiol, 296(4):C868-77

33.  Seong J., Lu, S., Ouyang M., Huang H., Zhang J., Frame MC., Wang Y. (2009) Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. Chemistry & Biology (Cell Press), 16(1):48-57, (Cover Article)

34.  Kim T., Seong J., Ouyang M., Sun, J., Lu, S., Hong J., Wang, N., Wang Y. (2009) Mechanical rigidity regulates Ca2+ oscillation via RhoA signaling pathway in human mesenchymal stem cells. Journal of Cellular Physiology, 218(2):285-93


35.  *Eichorst J., *Lu S., Xu J., Wang, Y. (2008) Differential RhoA Dynamics in Migratory and Stationary Cells Measured by FRET and Automated Image Analysis. PLoS ONE, 3(12):e4082

36.  Ouyang M., Sun J., Chien S., Wang Y. (2008) Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors, Proc Natl Acad Sci USA. 105(38):14353-8

37.  Wang, Y., Shyy Y.-J., Chien, S. (2008) Fluorescence Proteins, Live Cell Imaging, and Mechanobiology: Seeing is Believing, Annual Review of Biomedical Engineering, 10:1-38 (The most downloaded article of ARBE in year 2009)

38.  Lu S., Ouyang M., Seong J., Zhang J., Chien, S., Wang Y. (2008) The Spatiotemporal Pattern of Src Activation at Lipid Rafts Revealed by Diffusion-Corrected FRET Imaging. PLoS Computational Biology, 4(7): e1000127, (Featured Research by PLoS Computational Biology)

39.  Na S., Collin O., Chowdery F., Tay B., Ouyang M., Wang Y., Wang N. (2008) Rapid signal transduction in living cells is a unique feature of mechanotransduction. Proc Natl Acad Sci USA. 105 (18):6626-31

40.  Ouyang M., Lu S., Li X.-Y., Xu J., Seong J., Giepmans B., Shyy Y.-J., Weiss SJ, Wang Y. (2008) Directional MT1-MMP Activity in Live Cells Visualized by a FRET Biosensor, Journal of Biological Chemistry. 283 (25):17740-8

41.  Wang Y., Lu S. (2008) The Application of FRET Biosensors to Visualize Src Activation. Proc. of SPIE. 6868 (68680A):1-9

42.  Wang Y., Shyy, J.-Y., and Chien, S., (2008) “Fluorescence Live-Cell Imaging: Principles and Applications in Mechanobiology”. Bioengineering in Cell and Tissue Research, pp. 65-84


43.  Wang Y. and Chien, S., (2007) “Analysis of Integrin Signaling by Fluorescence Resonance Energy Transfer”. Methods in Enzymology, 426:177-201

44.  Botvinick, EL and Wang Y., (2007)Laser Tweezers in the Study of Mechanobiology in Live Cells”. Methods in Cell Biology, 82:497-523

45.  Wang Y., Chang JM., Chen K.-D., Li S., Li J., Wu C., Chien S. (2007) Selective Adapter Recruitment and Differential Signaling Networks by VEGF vs. Shear Stress. Proc Natl Acad Sci USA. 104 (21): 8875-9

46.  Larina IV., Wang Y., Chien S., Lane ME., and Dickinson ME. (2007) On the way to subcellular imaging of mechanotransduction in the developing vasculature. Proc. of SPIE. 6535 (653504):1-6


47.  Hu YL., Haga JH., Miao H., Wang Y., Li YS., Chien S. (2006) Roles of microfilaments and microtubules in paxillin dynamics. Biochem Biophys Res Commun. 348(4):1463-71.

48.  Wang Y., Jin G., Miao H., Li J., Usami S., Chien S. (2006) Integrins Regulate VE-cadherin and Catenins: Dependence of This Regulation on Src, but not on Ras. Proc Natl Acad Sci USA. 103(6):1774-79.


49.  Wang Y., Botvinick E., Zhao Y., Berns M., Usami S., Tsien R.Y., Chien S. (2005) Visualization of Mechanical Activation of Src. Nature. 434:1040.

50.  Miao H., Hu Y., Shiu Y.-T., Yuan S., Zhao Y., Kaunas R., Wang Y., Jin G., Usami S., and Chien S. (2005) Effects of Flow Patterns on the Localization and Expression of VE-Cadherin at Vascular Endothelial Cell Junctions: In-vivo and In-vitro Investigations. Journal of Vascular Research. 42:77.

51.  Wang Y., Chang JM., Li Y.-C., Li Y.-S., Shyy J. Y.-J., and Chien S. (2004) Shear Stress and VEGF Activate IKK via Flk-1/Cbl/Akt Signaling Pathway. Am J Physiol Heart Circ Physiol. 286(2):H685-92.

52.  Shiu Y.-T., Li S., Yuan S., Wang Y., Nguyen P., Chien S. (2003) Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner. Biochem Biophys Res Commun. 303(2):548-55

53.  Wang Y., Miao H., Li S., Chen K.-D., Li Y.-S., Yuan S., Shyy J. Y.-J., and Chien S., (2002) Interplay between integrins and FLK-1 in shear stress- induced signaling. Am J Physiol Cell Physiol.  283: C1540-1548

54.  Miao H., Yuan S., Wang Y., Tsygankov A., Chien S. (2002) Role of Cbl in Shear-Activation of PI 3-kinase and JNK in Endothelial Cells. Biochem Biophys Res Commun. 292(4):892-9

55.  Li S., Butler P., Wang Y., Hu Y., Han D., Usami S., Guan J.-L., Chien S. (2002). The role of the dynamic of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci USA 99(6):3546-51

56.  Wu W., Wang Y., Yan Z., Wen G. (1999). The Dynamic Coupling Model for the Whole Circulation in Human Body. Acta Scientiarum Naturalium, Universitatis Pekinensis 35(3): 328-339

57.  Wu W., Wen G., Yan Z., Wang Y., Zhang, Z. (1999). The Dynamic Coupling of Right Ventricle and Pulmonary Arteries. Acta Scientiarum Naturalium, Universitatis Pekinensis 35(3): 317-327

58.  Wang Y., Wu W., Wen G. (1999). The Influence of Aortic Valve on the Cardiovascular Coupling. Journal of Hydrodynamics 14(1): 13-23.

59.  Wang Y., Wu W., Wen G. (1998). The Influence of Cardiovascular Dynamic Coupling on the Blood Pulse Wave Propagation in Human Body. Applied Mathematics and Mechanics 19(7):601-614